Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R016135 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-BTK Rabbit mAb [92Q49A07]](https://files.epizyme.cn:5005/uploads/products/202601/R016135-1.png)
| Product Name | Anti-BTK Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 92Q49A07 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human BTK |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | AGMX1; AT; ATK; BPK; IGHD3; IMD1; PSCTK1; XLA; xid; BTK_HUMAN; BTK; Agammaglobulinemia tyrosine kinase (ATK); B-cell progenitor kinase (BPK); Bruton tyrosine kinase; 2.7.10.2; BTK_MOUSE; Kinase EMB. |
|---|---|
| Molecular weight | Calculated MW: 76 kDa; Observed MW: 76 kDa |
| Uniprot ID | Q06187 |
| Gene ID | 695 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-BTK Rabbit mAb [92Q49A07] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
|---|
| Cellular Location | Cytoplasm Cell membrane Peripheral membrane protein Nucleus Membrane raft In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. |
|---|
| Tissue Location | Predominantly expressed in B-lymphocytes. |
|---|
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