Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R016127 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-PTEN Rabbit mAb [70K11E55]](https://files.epizyme.cn:5005/uploads/products/202601/R016127-1.png)
![Anti-PTEN Rabbit mAb [70K11E55]](https://files.epizyme.cn:5005/uploads/products/202601/R016127-2.png)
| Product Name | Anti-PTEN Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 70K11E55 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human PTEN |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; PTENgama; TEP1; 2310035O07Rik; A130070J02Rik; B430203M17Rik; Mmac; PTEN_HUMAN; PTEN; Inositol polyphosphate 3-phosphatase; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; 3.1.3.16; 3.1.3.48; 3.1.3.67; PTEN_MOUSE. |
|---|---|
| Molecular weight | Calculated MW: 47 kDa; Observed MW: 54 kDa |
| Uniprot ID | P60484 |
| Gene ID | 5728 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-PTEN Rabbit mAb [70K11E55] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] |
|---|
| Cellular Location | Cytoplasm Nucleus Nucleus PML body Cell projection Dendritic spine Postsynaptic density Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Associares with the postsynaptic density in response to NMDAR activation (By similarity). Isoform alpha Secreted May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif. |
|---|
| Tissue Location | Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. |
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