Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R016077 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-Phospho-AMPK alpha 1/2 (Thr172) Rabbit mAb [14G44B99]](https://files.epizyme.cn:5005/uploads/products/202601/R016077-1.png)
| Product Name | Anti-Phospho-AMPK alpha 1/2 (Thr172) Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 14G44B99 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human AMPK alpha |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | PRKAA1 | AMPK alpha-1 (p-T172); p-AMPK alpha-1; phospho-AMPK alpha-1; AMPKalpha1; C130083N04Rik; AAPK1_MOUSE; Prkaa1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase (ACACA kinase); Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase); Tau-protein kinase PRKAA1; 2.7.11.1; AAPK1_RAT; Ampk1; AMPK; AMPK alpha 1; AMPKa1. |
|---|---|
| Molecular weight | Calculated MW: 62 kDa; Observed MW: 62 kDa |
| Uniprot ID | Q13131 , P54646 |
| Gene ID | 5562 , 5563 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Phospho-AMPK alpha 1/2 (Thr172) Rabbit mAb [14G44B99] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene belongs to the ser/thrprotein kinase family. It is the catalytic subunit of the5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellularenergy sensor conserved in all eukaryotic cells. The kinaseactivity of AMPK is activated by the stimuli that increase thecellular AMP/ATP ratio. AMPK regulates the activities of a numberof key metabolic enzymes through phosphorylation. It protects cellsfrom stresses that cause ATP depletion by switching offATP-consuming biosynthetic pathways. Alternatively splicedtranscript variants encoding distinct isoforms have been observed.[provided by RefSeq, Jul 2008]. The protein encoded by this gene is a catalytic subunit ofthe AMP-activated protein kinase (AMPK). AMPK is a heterotrimerconsisting of an alpha catalytic subunit, and non-catalytic betaand gamma subunits. AMPK is an important energy-sensing enzyme thatmonitors cellular energy status. In response to cellular metabolicstresses, AMPK is activated, and thus phosphorylates andinactivates acetyl-CoA carboxylase (ACC) and beta-hydroxybeta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved inregulating de novo biosynthesis of fatty acid and cholesterol.Studies of the mouse counterpart suggest that this catalyticsubunit may control whole-body insulin sensitivity and is necessaryfor maintaining myocardial energy homeostasis during ischemia.[provided by RefSeq, Jul 2008]. |
|---|
| Cellular Location | Cytoplasm Nucleus In response to stress, recruited by p53/TP53 to specific promoters. |
|---|
| Tissue Location | Cytoplasm Nucleus In response to stress, recruited by p53/TP53 to specific promoters. |
|---|
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