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Anti-SIRT5 Rabbit mAb [64P88G10]

Purified Recombinant Rabbit Monoclonal Antibody

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货号 规格 价格
R015952
20µL ¥588.00
50µL ¥1080.00
100µL ¥1780.00

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Anti-SIRT5 Rabbit mAb [64P88G10]
Anti-SIRT5 Rabbit mAb [64P88G10]
Anti-SIRT5 Rabbit mAb [64P88G10]
Anti-SIRT5 Rabbit mAb [64P88G10]
Product NameAnti-SIRT5 Rabbit mAb
DescriptionPurified Recombinant Rabbit Monoclonal Antibody
Application
  • Applications Legend:
  • WB=Western Blotting
  • IHC-P=Immunohistochemistry (Paraffin)
  • IHC-F=Immunohistochemistry (Frozen)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
 WB, IHC-P/IF (Tissue-P), ELISA
DilutionWB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200
ReactivityHuman, Mouse, Rat
HostRabbit
ClonalityMonoclonal
Clone No.64P88G10
IsotypeIgG
LabelUnconjugated
ImmunogenRecombinant protein of human SIRT5
FormatAffinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
SynonymsSIR2L5; SIRT5; Regulatory protein SIR2 homolog 5; SIR2-like protein 5.
Molecular weightCalculated MW: 34 kDa; Observed MW: 30 kDa
Uniprot ID Q9NXA8 , Q8K2C6 , Q68FX9
Gene ID 23408 , 68346 , 306840
StorageShipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
PrecautionsAnti-SIRT5 Rabbit mAb [64P88G10] is for research use only and not for use in diagnostic or therapeutic procedures.
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010] Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; oocyte; palatal shelf; sensory organ; and tibialis anterior. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Jul 2025] Predicted to enable several functions, including NAD+ binding activity; NAD-dependent protein lysine deacylase activity; and protein-malonyllysine demalonylase activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be active in cytosol; mitochondrial matrix; and nucleus. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Jul 2025]
Cellular Location Mitochondrion matrix Mitochondrion intermembrane space Cytoplasm Cytosol Nucleus Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus. Isoform 1 Cytoplasm Mitochondrion Isoform 2 Mitochondrion
Tissue Location Widely expressed

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