Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R015917 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit mAb [58A29J28]](https://files.epizyme.cn:5005/uploads/products/202511/R015917-1.png)
| Product Name | Anti-Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 58A29J28 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human Phospho-TAOK1/2/3 (S181 + S181 + S177) |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | KIAA0881; MAP3K17; PSK; PSK1; UNQ2971/PRO7431; TAOK2; Serine/threonine-protein kinase TAO2; Kinase from chicken homolog C; Prostate-derived sterile 20-like kinase 1; Thousand and one amino acid protein kinase 2; hKFC-C; PSK-1; Prostate-derived STE20-like kinase 1; KIAA1361; MAP3K16; MARKK; TAOK1; Serine/threonine-protein kinase TAO1; Kinase from chicken homolog B; MARK Kinase; Prostate-derived sterile 20-like kinase 2; Thousand and one amino acid protein kinase 1; hKFC-B; PSK-2; PSK2; Prostate-derived STE20-like kinase 2; hTAOK1; DPK; JIK; KDS; MAP3K18; TAOK3; Serine/threonine-protein kinase TAO3; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; Thousand and one amino acid protein 3; CTCL-associated antigen HD-CL-09; hKFC-A. |
|---|---|
| Molecular weight | Calculated MW: 116 kDa; Observed MW: 110-140 kDa |
| Uniprot ID | Q7L7X3 , Q9UL54 , Q9H2K8 |
| Gene ID | 57551 , 9344 , 51347 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit mAb [58A29J28] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | TAOK1: Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of MAPK cascade. Located in several cellular components, including microtubule cytoskeleton; nuclear body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] TAOK2: Enables mitogen-activated protein kinase kinase binding activity; neuropilin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; intracellular signal transduction; and positive regulation of MAPK cascade. Located in cytoplasmic vesicle; cytosol; and nuclear lumen. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025] TAOK3: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016] |
|---|
| Cellular Location | TAOK1: Cytoplasm. TAOK2: Cytoplasmic vesicle membrane; Multi-pass membrane protein Cytoplasm, cytoskeleton Nucleus Note: Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Isoform 2 Cell projection, dendrite Note: In dendrites, colocalizes with PCDH8. TAOK3: Cytoplasm Cell membrane; Peripheral membrane protein; Membrane raft Lipid droplet Note: Located primarily outside cell membrane rafts and remains outside upon canonical TCR ligation (PubMed:30373850). A small pool is detectable in cell membrane rafts in resting conditions but relocates outside the rafts upon TCR signaling (PubMed:30373850). Localizes to lipid droplets in hepatocytes (PubMed:34634521). |
|---|
| Tissue Location | TAOK1: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. TAOK2: Ubiquitously expressed, with a higher level of expression in testis and brain. TAOK3: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
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