Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R015844 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-GABBR1 Rabbit mAb [64F61F06]](https://files.epizyme.cn:5005/uploads/products/202510/R015844-1.png)
![Anti-GABBR1 Rabbit mAb [64F61F06]](https://files.epizyme.cn:5005/uploads/products/202510/R015844-2.png)
| Product Name | Anti-GABBR1 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 64F61F06 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human GABBR1 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | GPRC3A; GABBR1; Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1. |
|---|---|
| Molecular weight | Calculated MW: 108 kDa; Observed MW: 130,95 kDa |
| Uniprot ID | Q9UBS5 |
| Gene ID | 2550 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-GABBR1 Rabbit mAb [64F61F06] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016] |
|---|
| Cellular Location | Cell membrane.Multi-pass membrane protein.Postsynaptic cell membrane.Multi-pass membrane protein.Cell projection.Dendrite.Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512).Isoform 1E.Secreted. |
|---|
| Tissue Location | Highly expressed in brain (PubMed:9753614, PubMed:9844003, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333). |
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