Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R015841 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-ATRX Rabbit mAb [11G45T02]](https://files.epizyme.cn:5005/uploads/products/202510/R015841-1.png)
![Anti-ATRX Rabbit mAb [11G45T02]](https://files.epizyme.cn:5005/uploads/products/202510/R015841-2.png)
| Product Name | Anti-ATRX Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IF (Cell)/ICC, ELISA |
| Dilution | WB 1:1,000~1:2,000; IF 1:100~1:200 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 11G45T02 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein corresponding to the C-terminal of human ATRX |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | RAD54L; XH2; ATRX; Transcriptional regulator ATRX; ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; Znf-HX; XNP. |
|---|---|
| Molecular weight | Calculated MW: 282 kDa; Observed MW: 282 kDa |
| Uniprot ID | P46100 |
| Gene ID | 546 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-ATRX Rabbit mAb [11G45T02] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] |
|---|
| Cellular Location | Nucleus.Chromosome.Telomere.Nucleus.PML body.Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity). |
|---|
| Tissue Location | Ubiquitous. |
|---|
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