Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R015041 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-BCAR1 Rabbit mAb [28L05A78]](https://files.epizyme.cn:5005/uploads/products/202505/R015041-1.png)
![Anti-BCAR1 Rabbit mAb [28L05A78]](https://files.epizyme.cn:5005/uploads/products/202505/R015041-2.png)
| Product Name | Anti-BCAR1 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 28L05A78 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human BCAR1 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | BCAR 1, Bcar1, BCAR1_HUMAN, Breast cancer anti estrogen resistance 1, Breast cancer anti estrogen resistance 1 protein, Breast cancer anti-estrogen resistance protein 1, CAS, Cas scaffolding protein family member 1, CAS1, Cass1, Crk associated substrate, Crk associated substrate p130Cas, CRK-associated substrate, CRKAS, FLJ12176, FLJ45059, p130cas. |
|---|---|
| Molecular weight | Calculated MW: 93 kDa; Observed MW: 110 kDa |
| Uniprot ID | P56945 |
| Gene ID | 9564 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-BCAR1 Rabbit mAb [28L05A78] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] |
|---|
| Cellular Location | Cell junction, focal adhesion. Cytoplasm. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. |
|---|
| Tissue Location | Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line. |
|---|
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