Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R015000 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-PKN1 Rabbit mAb [65C51C39]](https://files.epizyme.cn:5005/uploads/productimage/R015000-1.png)
| Product Name | Anti-PKN1 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 65C51C39 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human PKN1 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | DBK, PAK 1, PAK-1, PAK1, PKC1, PKN ALPHA, PKN, Pkn1, PKN1_HUMAN, PRK1, PRKCL1, Protease activated kinase 1, Protease-activated kinase 1, Protein kinase C like 1, Protein kinase C like PKN, Protein kinase C related kinase 1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein kinase N1, Protein kinase PKN alpha, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, Serine threonine kinase N, Serine threonine protein kinase N, Serine-threonine protein kinase N, Serine/threonine protein kinase N1, Serine/threonine-protein kinase N1. |
|---|---|
| Molecular weight | Calculated MW: 104 kDa; Observed MW: 120 kDa |
| Uniprot ID | Q16512 |
| Gene ID | 5585 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-PKN1 Rabbit mAb [65C51C39] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
|---|
| Cellular Location | Cytoplasm. Nucleus. Endosome. Cell membrane. Cleavage furrow. Midbody. Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. |
|---|
| Tissue Location | Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. |
|---|
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