Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R014809 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-CA125/MUC16 Rabbit mAb [29K52H05]](https://files.epizyme.cn:5005/uploads/productimage/R014809-1.png)
![Anti-CA125/MUC16 Rabbit mAb [29K52H05]](https://files.epizyme.cn:5005/uploads/productimage/R014809-2.png)
![Anti-CA125/MUC16 Rabbit mAb [29K52H05]](https://files.epizyme.cn:5005/uploads/productimage/R014809-3.png)
| Product Name | Anti-CA125/MUC16 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 29K52H05 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human CA-125 (MUC16) |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | CA 125, CA-125, CA125, CA125 ovarian cancer antigen, Cancer antigen 125, FLJ14303, MUC 16, MUC-16, MUC16, MUC16_HUMAN, Mucin 16, Mucin 16 cell surface associated, Mucin-16, Mucin16, Ovarian cancer related tumor marker CA125, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125. |
|---|---|
| Molecular weight | Calculated MW: 1519 kDa; Observed MW: 1519 kDa |
| Uniprot ID | Q8WXI7 |
| Gene ID | 94025 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-CA125/MUC16 Rabbit mAb [29K52H05] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017] |
|---|
| Cellular Location | Cell membrane. Secreted > extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. |
|---|
| Tissue Location | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. |
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