Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R014355 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-LATS1/WARTS Rabbit mAb [88D85T19]](https://files.epizyme.cn:5005/uploads/productimage/R014355-1.png)
![Anti-LATS1/WARTS Rabbit mAb [88D85T19]](https://files.epizyme.cn:5005/uploads/productimage/R014355-2.png)
| Product Name | Anti-LATS1/WARTS Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 88D85T19 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human LATS1/WARTS |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | h-warts, Large tumor suppressor homolog 1, LATS large tumor suppressor homolog 1, LATS1, LATS1_HUMAN, Serine threonine protein kinase LATS1, Serine/threonine-protein kinase LATS1, WARTS, WARTS protein kinase, wts. |
|---|---|
| Molecular weight | Calculated MW: 127 kDa; Observed MW: 140 kDa |
| Uniprot ID | O95835 |
| Gene ID | 9113 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-LATS1/WARTS Rabbit mAb [88D85T19] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017] |
|---|
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. |
|---|
| Tissue Location | Expressed in all adult tissues examined except for lung and kidney. |
|---|
总篇数：加载中...
总影响因子：加载中...
最高影响因子：加载中...
上海市闵行区新骏环路760号1号楼3层
400-058-8030
技术支持(电话/微信)：
张老师 18217238522
罗老师 15021027255
李老师 18301721288
如有任何关于雅酶产品问题
欢迎来信咨询
雅酶微信公众号
Copyright © 2023上海雅酶生物医药科技有限公司（Epizyme Biotech）
沪ICP备2021002422号
