Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R014177 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-ITCH Rabbit mAb [70K15K56]](https://files.epizyme.cn:5005/uploads/productimage/R014177-1.png)
| Product Name | Anti-ITCH Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 70K15K56 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human ITCH |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | ADMFD, AIF4, AIP4, Atrophin 1 interacting protein 4, Atrophin-1-interacting protein 4, dJ468O1.1, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)), dJ468O1.1 atrophin 1 interacting protein 4 AIP4, E3 ubiquitin protein ligase Itchy homolog, E3 ubiquitin-protein ligase Itchy homolog, EC 6.3.2, Itch, ITCH_HUMAN, Itchy E3 ubiquitin protein ligase, Itchy E3 ubiquitin protein ligase homolog, Itchy E3 ubiquitin protein ligase homolog mouse, Itchy E3 ubiquitin protein ligase, mouse, homolog of, Itchy homolog E3 ubiquitin protein ligase, Itchy mouse homolog E3 ubiquitin protein ligase, NAPP1, NFE2 associated polypeptide 1, NFE2-associated polypeptide 1, Ubiquitin protein ligase ITCH. |
|---|---|
| Molecular weight | Calculated MW: 103 kDa; Observed MW: 103 kDa |
| Uniprot ID | Q96J02 |
| Gene ID | 83737 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-ITCH Rabbit mAb [70K15K56] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteosomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteosomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteosomal degradation of p15 BID. |
|---|
| Cellular Location | Cell membrane. Cytoplasm. Nucleus. Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1. |
|---|
| Tissue Location | Widely expressed. |
|---|
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