Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R013814 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-Phospho-Smad1 (Ser463/Ser465) Rabbit mAb [75G24K17]](https://files.epizyme.cn:5005/uploads/productimage/R013814-1.png)
| Product Name | Anti-Phospho-Smad1 (Ser463/Ser465) Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 75G24K17 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser463/Ser465 of human Smad1 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | BSP-1, JV4-1, MADH1, MADR1, Smad1 (phospho S463), p-Smad1 (Ser463), Mothers against decapentaplegic homolog 1, Dwarfin A, DwfA, hSMAD 1, MAD mothers against decapentaplegic homolog 1, Mad related protein 1, Mothers against DPP homolog 1, Sma and Mad related protein 1, SMAD-1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, SMAD1_HUMAN, MAD homolog 1, Mad-related protein 1, Transforming growth factor-beta-signaling protein 1. |
|---|---|
| Molecular weight | Calculated MW: 52 kDa; Observed MW: 60 kDa |
| Uniprot ID | Q15797 |
| Gene ID | 4086 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Phospho-Smad1 (Ser463/Ser465) Rabbit mAb [75G24K17] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
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