Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R012969 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-Phospho-IGF-I receptor beta (Tyr1166)/Insulin receptor beta (Tyr1190)/Insulin receptor-related protein beta (Tyr1146) Rabbit mAb [83L67L87]](https://files.epizyme.cn:5005/uploads/products/202601/R012969-1.png)
| Product Name | Anti-Phospho-IGF-I receptor beta (Tyr1166)/Insulin receptor beta (Tyr1190)/Insulin receptor-related protein beta (Tyr1146) Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 83L67L87 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr1166 of human INSR/IGF-1R |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | IGF1R (p-Y980); p-IGF1R; phospho-IGF1R; CD221; IGFIR; IGFR; JTK13; A330103N21Rik; D930020L01; IGF-1R; hyft; IGF-1 receptor; IGFIRC; Igfr1; IGF1R_HUMAN; IGF1R; Insulin-like growth factor I receptor (IGF-I receptor); 2.7.10.1; IGF1R_MOUSE; IGF1R_RAT. |
|---|---|
| Molecular weight | Calculated MW: 155 kDa; Observed MW: 95 kDa |
| Uniprot ID | P08069 |
| Gene ID | 3480 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | This product is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
|---|
| Cellular Location | Cell membrane Single-pass type I membrane protein |
|---|
| Tissue Location | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. |
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