Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R011345 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-APC Rabbit mAb [53L68M24]](https://files.epizyme.cn:5005/uploads/productimage/R011345-1.png)
| Product Name | Anti-APC Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Mouse, Rat, Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 53L68M24 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthetic peptide of human APC |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | Adenomatous Polyposis Coli, Adenomatous polyposis coli protein, Apc, APC_HUMAN, CC1, Deleted in polyposis 2.5, DP2, DP2.5, DP3, FPC, GS, Protein APC. |
|---|---|
| Molecular weight | Calculated MW: 312 kDa; Observed MW: 160 kDa |
| Uniprot ID | P25054 |
| Gene ID | 324 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-APC antibody [53L68M24] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
|---|
| Cellular Location | Cell junction > adherens junction. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. |
|---|
| Tissue Location | Expressed in a variety of tissues. |
|---|
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