Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R011230 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-Cip4 Rabbit mAb [47K66L51]](https://cdn.epizyme.cn/uploads/productimage/R011230-1.png?v=20241220135155)
![Anti-Cip4 Rabbit mAb [47K66L51]](https://cdn.epizyme.cn/uploads/productimage/R011230-2.png?v=20241220135155)
| Product Name | Anti-Cip4 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:3,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 47K66L51 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human Cip4 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | Cdc42 interacting protein 4, Cdc42 interaction protein 4 long isoform, Cdc42-interacting protein 4, CG11341, CG15015 PA, Cip 4, CIP4, CIP4_HUMAN, DCIP4, hSTP, Protein Felic, Salt tolerant protein, Salt tolerator, STOT, STP, Thyroid hormone receptor interactor 10, Thyroid receptor interacting protein 10, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP 10, TRIP-10, trip10, Truncated Cdc42 interaction protein 4. |
|---|---|
| Molecular weight | Calculated MW: 68 kDa; Observed MW: 80 kDa |
| Uniprot ID | Q15642 |
| Gene ID | 9322 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Cip4 Rabbit mAb [47K66L51] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
|---|
| Cellular Location | Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. |
|---|
| Tissue Location | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
|---|
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