Purified Recombinant Rabbit Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| R010594 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-SLC31A1 Rabbit mAb [44L05K08]](https://files.epizyme.cn:5005/uploads/products/202511/R010594-1.png)
| Product Name | Anti-SLC31A1 Rabbit mAb |
|---|---|
| Description | Purified Recombinant Rabbit Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 44L05K08 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human SLC31A1/CTR1 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | COPT1; CTR1; SLC31A1; High affinity copper uptake protein 1; Copper transporter 1; Solute carrier family 31 member 1; hCTR1. |
|---|---|
| Molecular weight | Calculated MW: 21 kDa; Observed MW: 26-34 kDa |
| Uniprot ID | O15431 |
| Gene ID | 1317 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-SLC31A1 Rabbit mAb [44L05K08] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011] |
|---|
| Cellular Location | Cell membrane.Multi-pass membrane protein.Early endosome membrane.Multi-pass membrane protein.Recycling endosome membrane.Multi-pass membrane protein.Apical cell membrane.Multi-pass membrane protein.Late endosome membrane.Multi-pass membrane protein.Basolateral cell membrane.Multi-pass membrane protein.The localization is controlled by the intra and extra-cellular copper concentration (PubMed:15326162, PubMed:19740744, PubMed:23658018, PubMed:26205368, PubMed:26945057). Under conditions of elevated extracellular copper concentrations, it is rapidly internalized by endocytosis from the plasma membrane by a clathrin- and dynamin-mediated process and degradated in order to prevent intracellular copper accumulation and to reduce the transport of the copper across the membrane (PubMed:15326162, PubMed:19740744, PubMed:23658018, PubMed:26205368, PubMed:26945057). The internalized SLC31A1 is then localized in early endosomes, and, upon a low extracellular copper concentrations, it is transported back to the plasma membrane in a RAB11A-dependent recycling pathway (PubMed:26945057). Localizes to the apical membrane in intestinal epithelial cells (By similarity). Mainly localized on the basolateral side of renal tubular cells (By similarity). Localizes to the neuronal cell body plasma membranes (By similarity). |
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