网站首页

抗体系列

Anti-BRCC36 Rabbit mAb [92L85K61]

Purified Recombinant Rabbit Monoclonal Antibody

一键复制产品信息
货号 规格 价格
R010353
20µL ¥588.00
50µL ¥1080.00
100µL ¥1780.00

立即购买
Anti-BRCC36 Rabbit mAb [92L85K61]
Product NameAnti-BRCC36 Rabbit mAb
DescriptionPurified Recombinant Rabbit Monoclonal Antibody
Application
  • Applications Legend:
  • WB=Western Blotting
  • IHC-P=Immunohistochemistry (Paraffin)
  • IHC-F=Immunohistochemistry (Frozen)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
 WB, ELISA
DilutionWB 1:1,000~1:5,000
ReactivityHuman, Mouse, Rat
HostRabbit
ClonalityMonoclonal
Clone No.92L85K61
IsotypeIgG
LabelUnconjugated
ImmunogenA synthesized peptide derived from human BRCC36
FormatAffinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
SynonymsBRCC36; C6.1A; CXorf53; BRCC3; Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36.
Molecular weightCalculated MW: 36 kDa; Observed MW: 36 kDa
Uniprot ID P46736
Gene ID 79184
StorageShipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
PrecautionsAnti-BRCC36 Rabbit mAb [92L85K61] is for research use only and not for use in diagnostic or therapeutic procedures.
Background This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Cellular Location Nucleus.Cytoplasm.Cytoplasm.Cytoskeleton.Spindle pole.Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:20656690, PubMed:26344097). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm (PubMed:20656690).
Tissue Location Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors.

说明书下载

总篇数：加载中...

总影响因子：加载中...

最高影响因子：加载中...

加载中...
没有更多数据

产品中心 / 一抗和流式抗体 / 一抗

返回产品列表

产品中心

回到顶部

联系雅酶

上海市闵行区新骏环路760号1号楼3层

info@epizyme.cn

400-058-8030

技术支持(电话/微信)：

张老师 18217238522

罗老师 15021027255

李老师 18301721288

如有任何关于雅酶产品问题
欢迎来信咨询

雅酶微信公众号

微信公众号

Copyright © 2023上海雅酶生物医药科技有限公司（Epizyme Biotech）

沪ICP备2021002422号