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Anti-Phospho-Chk1 (Ser345) Rabbit pAb

Purified Rabbit Polyclonal Antibody

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货号 规格 价格
P108746
20µL ¥588.00
50µL ¥1080.00
100µL ¥1780.00

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Anti-Phospho-Chk1 (Ser345) Rabbit pAb
Product NameAnti-Phospho-Chk1 (Ser345) Rabbit pAb
DescriptionPurified Rabbit Polyclonal Antibody
Application
  • Applications Legend:
  • WB=Western Blotting
  • IHC-P=Immunohistochemistry (Paraffin)
  • IHC-F=Immunohistochemistry (Frozen)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ELISA
DilutionWB 1:100~1:500
ReactivityHuman, Mouse, Rat
HostRabbit
ClonalityPolyclonal
IsotypeIgG
LabelUnconjugated
ImmunogenA synthetic phosphorylated peptide around S345 of human Chk1 (NP_001265.2).
FormatAffinity purified polyclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
SynonymsCHK1; Phospho-Chk1-S345.
Molecular weightCalculated MW: 54 kDa; Observed MW: 56 kDa
Uniprot ID O14757
Gene ID 1111
StorageShipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
PrecautionsAnti-Phospho-Chk1 (Ser345) Rabbit pAb is for research use only and not for use in diagnostic or therapeutic procedures.
Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

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