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Anti-ITPR2 Rabbit pAb

Purified Rabbit Polyclonal Antibody

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货号 规格 价格
P104243
20µL ¥588.00
50µL ¥1080.00
100µL ¥1780.00

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Anti-ITPR2 Rabbit pAb
Anti-ITPR2 Rabbit pAb
Anti-ITPR2 Rabbit pAb
Anti-ITPR2 Rabbit pAb
Product NameAnti-ITPR2 Rabbit pAb
DescriptionPurified Rabbit Polyclonal Antibody
Application
  • Applications Legend:
  • WB=Western Blotting
  • IHC-P=Immunohistochemistry (Paraffin)
  • IHC-F=Immunohistochemistry (Frozen)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P/IF (Tissue-P), IF (Cell)/ICC, ELISA
DilutionIHC-P 1:50~1:200; IF 1:50~1:200
ReactivityHuman, Mouse, Rat
HostRabbit
ClonalityPolyclonal
IsotypeIgG
LabelUnconjugated
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 2415-2480 of human ITPR2 (NP_002214.2).
FormatAffinity purified polyclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
SynonymsANHD; IP3R2; CFAP48; INSP3R2; ITPR2.
Molecular weightCalculated MW: 308 kDa; Observed MW: Refer to figures
Uniprot ID Q14571
Gene ID 3709
StorageShipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
PrecautionsAnti-ITPR2 Rabbit pAb is for research use only and not for use in diagnostic or therapeutic procedures.
Background The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

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