Purified Rabbit Polyclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| P012594 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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| Product Name | Anti-Phospho-JAK2/3 (Tyr966/939) Rabbit pAb |
|---|---|
| Description | Purified Rabbit Polyclonal Antibody |
Application
|
ELISA, WB |
| Dilution | WB 1:500~1:1,000; ELISA 1:10,000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Synthesized Phospho peptide derived from human JAK2/3. |
| Format | Buffer System: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Purification: Affinity Purified. |
| Synonyms | Tyrosine-protein kinase JAK2/JAK3 (EC 27102, Janus kinase 2/Janus kinase 3, JAK-2/JAK-3). |
|---|---|
| Molecular weight | Calculated MW: 131 kDa; Observed MW: 120-130 kDa |
| Uniprot ID | O60674 , P52333 |
| Gene ID | 3717 , 3718 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Phospho-JAK2/3 (Tyr966/939) antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. |
|---|
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