Purified Rabbit Polyclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| P012435 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
| Product Name | Anti-Phospho-LRRK2 (Ser395) Rabbit pAb |
|---|---|
| Description | Purified Rabbit Polyclonal Antibody |
Application
|
WB, ICC/IF (Cell), ELISA |
| Dilution | WB 1:500~1:1,000; IF 1:50~1:200 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human Phospho-LRRK2 (S935) |
| Format | Buffer System: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Purification: Affinity Chromatography |
| Synonyms | AURA17, Dardarin antibody, , Leucine rich repeat kinase 2, LRRK 2 antibody, LRRK2, LRRK2_HUMAN, PARK 8, PARK8, RIPK7, ROCO 2, ROCO2. |
|---|---|
| Molecular weight | Calculated MW: 286 kDa; Observed MW: 286 kDa |
| Uniprot ID | Q5S007 |
| Gene ID | 120892 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Phospho-LRRK2 (Ser395) antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. |
|---|
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