Purified Rabbit Polyclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| P010452 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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| Product Name | Anti-Daxx Rabbit pAb |
|---|---|
| Description | Purified Rabbit Polyclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ICC/IF (Cell), FC, ELISA |
| Dilution | WB 1:500~1:1,000; IHC-P 1:50~1:100; IF 1:50~1:200; FC 1:50~1:100 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human Daxx |
| Format | Buffer System: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Purification: Affinity Chromatography |
| Synonyms | DAXX, BING2, DAP6, Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein. |
|---|---|
| Molecular weight | Calculated MW: 81 kDa; Observed MW: 110 kDa |
| Uniprot ID | Q9UER7 |
| Gene ID | 1616 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Daxx antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted. |
|---|
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