Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M900053 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-phospho-Smad2/3(Thr8) Mouse mAb [61A83P70]](https://cdn.epizyme.cn/uploads/products/202608/M900053-1.png?v=20260826172606)
![Anti-phospho-Smad2/3(Thr8) Mouse mAb [61A83P70]](https://cdn.epizyme.cn/uploads/products/202608/M900053-2.png?v=20260826172606)
![Anti-phospho-Smad2/3(Thr8) Mouse mAb [61A83P70]](https://cdn.epizyme.cn/uploads/products/202608/M900053-3.png?v=20260826172606)
![Anti-phospho-Smad2/3(Thr8) Mouse mAb [61A83P70]](https://cdn.epizyme.cn/uploads/products/202608/M900053-4.png?v=20260826172606)
| Product Name | Anti-phospho-Smad2/3(Thr8) Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), IF (Cell)/ICC, ELISA |
| Dilution | WB 1:1,000~1:2,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 61A83P70 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr8 of human Smad2 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | hMAD 2; hMAD 3; hSMAD2; hSMAD3; Mad related protein 2; MADH2; MADH3; MADR2; Mothers against DPP homolog 2; Mothers against DPP homolog 3; Sma and Mad related protein 2; SMA and MAD related protein 3; SMAD 2; SMAD 3; SMAD family member 2; SMAD family member 3; smad2+3; smad2/3. |
|---|---|
| Molecular weight | Calculated MW: 52 kDa; Observed MW: 52 kDa |
| Uniprot ID | Q15796 |
| Gene ID | 4087 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-phospho-Smad2/3(Thr8) Mouse mAb [61A83P70] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
|---|
| Cellular Location | Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. |
|---|
| Tissue Location | Expressed at high levels in skeletal muscle, heart and placenta. |
|---|
总篇数：加载中...
总影响因子：加载中...
最高影响因子：加载中...
上海市闵行区新骏环路760号1号楼3层
400-058-8030
技术支持(电话/微信)：
罗老师 15021027255
李老师 18301721288
黄老师 18217238522
如有任何关于雅酶产品问题
欢迎来信咨询
雅酶微信公众号
Copyright © 2026上海雅酶生物医药科技有限公司（Epizyme Biotech）
沪ICP备2021002422号
