Anti-Cathepsin S Mouse mAb [47R74T72]

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Anti-Cathepsin S Mouse mAb [47R74T72]

Purified Recombinant Mouse Monoclonal Antibody

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货号	规格	价格
M016163
	20µL	¥588.00
	50µL	¥1080.00
	100µL	¥1780.00

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Western Blot - Anti-Cathepsin S Mouse mAb [47R74T72]

All lanes: M016163 at 1:1,000 dilution

Lane 1: A431 (Human epidermoid teratoma cell line) whole cell lysates

Lane 2: MCF-7 (human breast adenocarcinoma epithelial cell) whole cell lysates

Lane 3: U87 (Human malignant glioblastoma epithelial cell) whole cell lysates

Lane 4: THP-1 (Human monocytic leukemia cell) whole cell lysates

Lane 5: K562 (Human chronic myeloid leukemia cell) whole cell lysates

Lysates/proteins at 20 µg per lane.

Secondary antibody: Goat Anti-Mouse IgG (H+L), HRP conjugated (LF101) with dilution of 1:2,000

Predicted band size: 25, 37 kDa

Observed band size: 22, 37 kDa

Developed using the ECL technique (Cat. No. SQ201).

Western Blot - Anti-Cathepsin S Mouse mAb [47R74T72]

All lanes: M016163 at 1:1,000 dilution

Lane 1: Mouse liver whole tissue lysates

Lane 2: Mouse muscle whole tissue lysates

Lysates/proteins at 20 µg per lane.

Secondary antibody: Goat Anti-Mouse IgG (H+L), HRP conjugated (LF101) with dilution of 1:2,000

Predicted band size: 25, 37 kDa

Observed band size: 22 kDa

Developed using the ECL technique (Cat. No. SQ201).

Product Name	Anti-Cathepsin S Mouse mAb
Description	Purified Recombinant Mouse Monoclonal Antibody
Application Applications Legend: WB=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, ELISA
Dilution	WB 1:1,000~1:2,000
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Clone No.	47R74T72
Isotype	IgG
Label	Unconjugated
Immunogen	Recombinant protein of human Cathepsin S
Format	Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.

Synonyms	Cats; CTSS; Cathepsin S.
Molecular weight	Calculated MW: 25, 37 kDa; Observed MW: 22, 37 kDa
Uniprot ID	P25774
Gene ID	1520
Storage	Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
Precautions	Anti-Cathepsin S Mouse mAb [47R74T72] is for research use only and not for use in diagnostic or therapeutic procedures.

Background	The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2020]

Background

The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2020]

Cellular Location	Lysosome. Secreted. Cytoplasmic vesicle, phagosome.

Tissue Location	Tissue enhanced (Bone marrow, Lymphoid tissue). Expressed in monocyte and 182 other cell types or tissues.

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M016163 Anti-Cathepsin S Mouse mAb [47R74T72]

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