Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M015252 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-beta Catenin Mouse mAb [97L64M20]](https://files.epizyme.cn:5005/uploads/products/202506/M015252-1.png)
![Anti-beta Catenin Mouse mAb [97L64M20]](https://files.epizyme.cn:5005/uploads/products/202506/M015252-2.png)
![Anti-beta Catenin Mouse mAb [97L64M20]](https://files.epizyme.cn:5005/uploads/products/202506/M015252-3.png)
| Product Name | Anti-beta Catenin Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:4,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Human, Mouse (Cell), Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 97L64M20 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | A synthesized peptide derived from human beta Catenin |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | b-catenin; Beta catenin; Beta-catenin; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CHBCAT; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289. |
|---|---|
| Molecular weight | Calculated MW: 86 kDa; Observed MW: 86 kDa |
| Uniprot ID | P35222 |
| Gene ID | 1499 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-beta Catenin Mouse mAb [97L64M20] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] |
|---|
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell junction. Cell membrane. Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. |
|---|
| Tissue Location | Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. |
|---|
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