Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M014684 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-Rad51 Mouse mAb [36Q01I01]](https://files.epizyme.cn:5005/uploads/productimage/M014684-1.png)
![Anti-Rad51 Mouse mAb [36Q01I01]](https://files.epizyme.cn:5005/uploads/productimage/M014684-2.png)
| Product Name | Anti-Rad51 Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
WB, IHC-P/IF (Tissue-P), ELISA |
| Dilution | WB 1:1,000~1:4,000; IHC-P 1:100~1:200; IF 1:100~1:200 |
| Reactivity | Mouse (Cell), Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 36Q01I01 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human Rad51 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | BRCA1/BRCA2 containing complex, subunit 5, BRCC 5, BRCC5, DNA repair protein RAD51 homolog 1, DNA repair protein rhp51, FANCR, hRAD51, HsRAD51, HsT16930, MRMV2, Rad 51, RAD51, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), RAD51 homolog A, RAD51 homolog, RAD51 recombinase, RAD51, S. cerevisiae, homolog of, RAD51_HUMAN, RAD51A, RECA, RecA like protein, RecA, E. coli, homolog of, Recombination protein A. |
|---|---|
| Molecular weight | Calculated MW: 37 kDa; Observed MW: 37 kDa |
| Uniprot ID | Q06609 |
| Gene ID | 5888 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Rad51 Mouse mAb [36Q01I01] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:<a href="http://www.uniprot.org/citations/28575658" target="_blank">28575658</a>). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:<a href="http://www.uniprot.org/citations/26681308" target="_blank">26681308</a>). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:<a href="http://www.uniprot.org/citations/26253028" target="_blank">26253028</a>). |
|---|
| Cellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. |
|---|
| Tissue Location | Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast. |
|---|
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