Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M014634 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
立即购买
![Anti-CDK4 Mouse mAb [41I99E38]](https://files.epizyme.cn:5005/uploads/productimage/M014634-1.png)
![Anti-CDK4 Mouse mAb [41I99E38]](https://files.epizyme.cn:5005/uploads/productimage/M014634-2.png)
| Product Name | Anti-CDK4 Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
ELISA, WB, IF (Cell)/ICC |
| Dilution | WB 1:1,000~1:2,000; IF 1:100~1:200 |
| Reactivity | Human, Mouse (Cell) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 41I99E38 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human CDK4 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | Cdk 4, cdk4, CDK4 protein, CDK4_HUMAN, Cell division kinase 4, Cell division protein kinase 4, CMM 3, CMM3, Crk3, Cyclin dependent kinase 4, Cyclin-dependent kinase 4, Melanoma cutaneous malignant 3, MGC14458, p34 cdk4, PSK J3, PSK-J3. |
|---|---|
| Molecular weight | Calculated MW: 33 kDa; Observed MW: 33 kDa |
| Uniprot ID | P11802 |
| Gene ID | 1019 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-CDK4 Mouse mAb [41I99E38] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
|---|
| Cellular Location | Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. |
|---|
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