Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M014383 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-Raptor Mouse mAb [11I28K70]](https://files.epizyme.cn:5005/uploads/productimage/M014383-1.png)
| Product Name | Anti-Raptor Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
WB, ELISA |
| Dilution | WB 1:1,000~1:2,000 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 11I28K70 |
| Isotype | IgG |
| Label | Unconjugated |
| Immunogen | Recombinant protein of human COX2/Cyclooxygenase 2 |
| Format | Affinity purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. |
| Synonyms | KIAA1303, KOG1, Mip1, P150 target of rapamycin (TOR) scaffold protein, p150 target of rapamycin (TOR) scaffold protein containing WD repeats, P150 target of rapamycin (TOR)-scaffold protein, Raptor, Regulatory associated protein of mTOR, Regulatory associated protein of MTOR complex 1, Regulatory-associated protein of mTOR, RPTOR, RPTOR_HUMAN. |
|---|---|
| Molecular weight | Calculated MW: 149 kDa; Observed MW: 140 kDa |
| Uniprot ID | Q8N122 |
| Gene ID | 57521 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-Raptor Mouse mAb [11I28K70] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. |
|---|
| Cellular Location | Cytoplasm. Lysosome. Targeting to lysosomes depends on amino acid availability. |
|---|
| Tissue Location | Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. |
|---|
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