Anti-Smad2/3 Mouse mAb [82L23L50]

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Anti-Smad2/3 Mouse mAb [82L23L50]

Purified Mouse Monoclonal Antibody

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货号	规格	价格
M012855
	20µL	¥588.00
	50µL	¥1080.00
	100µL	¥1780.00

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Immunohistochemistry analysis of paraffin-embedded Human Live rTissue using Smad2/3 antibody [82L23L50]. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemical analysis of paraffin-embedded Human tonsils using Smad2/3 antibody [82L23L50]. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Smad2/3 in C6, MCF-7, Jurkat and 3T3 lysates using Smad2/3 antibody [82L23L50].

Product Name	Anti-Smad2/3 Mouse mAb
Description	Purified Mouse Monoclonal Antibody
Application Applications Legend: WB=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P/IF (Tissue-P), WB, ELISA
Dilution	WB 1:500~1:1,000; IHC-P 1:50~1:100
Reactivity	Human, Rat, Mouse (Cell)
Host	Mouse
Clonality	Monoclonal
Clone No.	82L23L50
Isotype	IgG
Label	Unconjugated
Immunogen	Recombinant Protein of Smad3
Format	Buffer System: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Purification: Affinity Purified.

Synonyms	SMAD3, MADH3, Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3.
Molecular weight	Calculated MW: 52 kDa; Observed MW: 52,60 kDa
Uniprot ID	P84022 , Q15796
Gene ID	4087 , 4088
Storage	Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
Precautions	Anti-Smad2/3 antibody [82L23L50] is for research use only and not for use in diagnostic or therapeutic procedures.

Background	Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 . Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses .

Background

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 . Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses .

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M012855 Anti-Smad2/3 Mouse mAb [82L23L50]

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