Anti-PAK2 Mouse mAb [35M51M90]

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Anti-PAK2 Mouse mAb [35M51M90]

Purified Recombinant Mouse Monoclonal Antibody

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货号	规格	价格
M010619
	20µL	¥588.00
	50µL	¥1080.00
	100µL	¥1780.00

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Western Blot - Anti-PAK2 Mouse mAb [35M51M90]

All lanes: M010619 at 1:1,000 dilution

Lane 1: HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysates

Lane 2: HepG2 (Human hepatocarcinoma epithelial cell) whole cell lysates

Lane 3: MCF-7 (human breast adenocarcinoma epithelial cell) whole cell lysates

Lane 4: 293T (Human embryonic kidney cell) whole cell lysates

Lane 5: U87 (Human malignant glioblastoma epithelial cells) whole cell lysates

Lysates/proteins at 10 µg per lane.

Secondary antibody: Goat Anti-Mouse IgG(H+L), HRP Conjugated (Cat. No. LF101) at 1:5,000 dilution

Predicted band size: 58 kDa

Observed band size: 58 kDa

Developed using the ECL technique (Cat. No. SQ201).

Product Name	Anti-PAK2 Mouse mAb
Description	Purified Recombinant Mouse Monoclonal Antibody
Application Applications Legend: WB=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, ELISA
Dilution	WB 1:1,000~1:2,000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Clone No.	35M51M90
Isotype	IgG
Label	Unconjugated
Immunogen	Recombinant protein of human PAK2
Format	Affinity purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.

Synonyms	KNO2; PAK65; PAKgamma; 5330420P17Rik; A130002K10Rik; D16Ertd269e; PAK-2; mKIAA4182; gamma-PAK; PAK2_HUMAN; PAK2; S6/H4 kinase; p21-activated kinase 2 (PAK-2); p58; 2.7.11.1; PAK2_MOUSE; PAK2_RAT.
Molecular weight	Calculated MW: 58 kDa; Observed MW: 58 kDa
Uniprot ID	Q13177
Gene ID	5062
Storage	Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage.
Precautions	Anti-PAK2 Mouse mAb [35M51M90] is for research use only and not for use in diagnostic or therapeutic procedures.

Background	The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Background

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Cellular Location	Serine/threonine-protein kinase PAK 2 Cytoplasm Nucleus MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. PAK-2p34 Nucleus Cytoplasm Perinuclear region Membrane Lipid-anchor Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region (PubMed:15471851). Myristoylation changes PAK-2p34 location to the membrane (PubMed:16617111).

Cellular Location

Serine/threonine-protein kinase PAK 2 Cytoplasm Nucleus MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. PAK-2p34 Nucleus Cytoplasm Perinuclear region Membrane Lipid-anchor Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region (PubMed:15471851). Myristoylation changes PAK-2p34 location to the membrane (PubMed:16617111).

Tissue Location	Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.

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M010619 Anti-PAK2 Mouse mAb [35M51M90]

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