Purified Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M010542 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-AKT Mouse mAb [31M99M18]](https://files.epizyme.cn:5005/uploads/antybody/M010542_1.jpg)
![Anti-AKT Mouse mAb [31M99M18]](https://files.epizyme.cn:5005/uploads/antybody/M010542_2.jpg)
![Anti-AKT Mouse mAb [31M99M18]](https://files.epizyme.cn:5005/uploads/antybody/M010542_3.jpg)
| Product Name | Anti-AKT Mouse mAb |
|---|---|
| Description | Purified Mouse Monoclonal Antibody |
Application
|
WB, IP, ELISA |
| Dilution | WB 1:500~1:1,000; IP 1:20 |
| Reactivity | Human, Mouse (Cell), Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 31M99M18 |
| Isotype | IgG1 |
| Label | Unconjugated |
| Immunogen | Purified recombinant human AKT1 protein fragments expressed in E.coli.AKT1 interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding By similarity. Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with RAF1. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with TNK2 and CLK2. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with and phosphorylated by PDPK1.AKT2 interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CLK2, PBH2 and TRAF6. AKT3 interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6. |
| Format | Buffer System: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Purification: Affinity Purified. |
| Synonyms | AKT1. |
|---|---|
| Molecular weight | Calculated MW: 56 kDa; Observed MW: 60 kDa |
| Uniprot ID | P31749 , P31751 , Q9Y243 |
| Gene ID | 207 , 208 , 10000 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-AKT antibody [31M99M18] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. |
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