| 货号 | 规格 | 价格 |
|---|---|---|
| FL178 | ||
| 5μg | ¥198.00 | |
| 20μg | ¥918.00 | |
| 50μg | ¥1680.00 | |
| 100μg | ¥2980.00 | |
| 500μg | ¥6680.00 | |
| 1mg | ¥13400.00 |
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| Appearance | Sterile filtered White lyophilized (freeze-dried) powder. |
|---|---|
| Purity | > 98% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.1 EU/μg of rHuIL-4 protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Human |
| Tag | Tag free. |
| Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.2 ng/ml, corresponding to a specific activity of ≥ 5.0×10^6 IU/mg. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 150 mM NaCl, 0.02% (v/v) Tween-20, pH 5.0. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | P05112 His25-Ser153 |
|---|---|
| Amino acid sequence | HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
| Molecular weight | Approximately 15.0 kDa, 129 amino acids. |
| Synonyms | BCGF, BCDF, B cell stimulating factor (BSF-1) |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Human IL-4 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Interleukin-4 (IL-4) is a pleiotropic cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells and produced primarily by mast cells, Th2 cells, eosinophils and basophils. IL-4 is a key regulator in humoral and adaptive immunity and has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It regulates the differentiation of naive CD4+ T cells into helper Th2 cells and immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells is associated with allergies. Mature human IL-4 shares 55%, 39% and 43% aa sequence identity with bovine, mouse, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities. IL-4 has a compact, globular fold, stabilized by 3 disulfide bonds. The recombinant Interleukin-4 is a 15kDa protein consisting of 129amino acid. |
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