| 货号 | 规格 | 价格 |
|---|---|---|
| FL173 | ||
| 2μg | ¥198.00 | |
| 10μg | ¥998.00 | |
| 50μg | ¥2780.00 | |
| 100μg | ¥4980.00 | |
| 500μg | ¥11900.00 | |
| 1mg | ¥23800.00 |
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| Appearance | Sterile filtered White lyophilized (freeze-dried) powder. |
|---|---|
| Purity | > 96% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.1 EU/μg of rRtIL-6 protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Rat |
| Tag | Tag free. |
| Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.01 ng/ml, corresponding to a specific activity of ≥ 1.0×10^8 IU/mg. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 150 mM NaCl, 5% (v/v) Trehalose, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | P20607 Phe25-Thr211 |
|---|---|
| Amino acid sequence | FPTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT |
| Molecular weight | Approximately 21.7 kDa, a single non-glycosylated polypeptide chain containing 187 amino acids. |
| Synonyms | BSF-2, CDF, Hybridoma growth factor, IFN-beta-2 |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Rat IL-6 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Interleukin-6 (IL-6) is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. The rat IL-6 shares 40% and 85% aa sequence identity with human and mouse IL-6 and it is equally active on human and mouse cells. Recombinant Rat IL-6 is a 21.7kDa protein containing 187 amino acid. |
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