| 货号 | 规格 | 价格 |
|---|---|---|
| FL131 | ||
| 2μg | ¥198.00 | |
| 10μg | ¥998.00 | |
| 50μg | ¥2780.00 | |
| 100μg | ¥4980.00 | |
| 500μg | ¥11900.00 | |
| 1mg | ¥23800.00 |
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| Appearance | Sterile filtered White lyophilized (freeze-dried) powder. |
|---|---|
| Purity | > 97% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.01 EU/μg of rHuIL-22 protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Human |
| Tag | Tag free. |
| Activity | Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.3 ng/ml, corresponding to a specific activity of ≥ 3.3×10^6 IU/mg. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 150 mM NaCl, pH 5.0. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | Q9GZX6 Ala34-Ile179 |
|---|---|
| Amino acid sequence | MAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI |
| Molecular weight | Approximately 33.6 kDa, a non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. |
| Synonyms | nterleukin-22, IL-TIF, Cytokine ZCYTO18 |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Human IL-22 is for research use only and not for use in diagnostic or therapeutic procedures. |
| IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. The human IL-22 gene is localized to chromosome 12q15. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4) , belonging to the class II cytokine receptor family. Mature human IL-22 protein shares approximately 79% aa sequence identity with mouse IL-22. Recombinant Human IL-22 is a 33.6kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. |
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