| 货号 | 规格 | 价格 |
|---|---|---|
| FL034 | ||
| 5μg | ¥198.00 | |
| 20μg | ¥918.00 | |
| 50μg | ¥2280.00 | |
| 100μg | ¥3480.00 | |
| 1mg | ¥17600.00 |
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| Appearance | Sterile colorless liquid. |
|---|---|
| Purity | > 96% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.01 EU/μg of rHuP16-INK4a-TAT protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Human |
| Tag | Tag free. |
| Concentration | No less than 10mg/ml, The concentration for a specific batch as shown in the COA |
| Formulation | A 0.2 μm filtered concentrated solution in 20 mM PB, with 500 mM NaCl, 50% (v/v) Glycerol, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile aqueous buffer to an appropriate concentration. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | P42771 Met1-Asp156 with a 12-residue C-terminal TAT peptide |
|---|---|
| Amino acid sequence | MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPDGYGRKKRRQRRR |
| Molecular weight | Approximately 18.0 kDa, a single non-glycosylated polypeptide chain containing 167 amino acids. |
| Synonyms | CDK4I, MTS-1, p16INK4A |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Human p16INK4a-TAT is for research use only and not for use in diagnostic or therapeutic procedures. |
| Cyclin-dependent kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity of CDKs. Two major classes of CDK inhibitors have been identified. The p16 family (p15, p16, p18 and p19) binds to and inhibits the activities of CDK4 and CDK6. The p21 family (p21, p27, p28 and p57) can bind to broad range of CDK-cyclin complexes and inhibit their activities. CDKIs are capable of suppressing growth, and several lines of evidence strongly suggest that at least some CDKIs may be tumor suppressor proteins. p16-INK4A is the member of p16 family and is encoded by CDKN2A gene in humans. It has three isoforms, which are wildly expressed but not detected in brain or skeletal muscle, except that isoform 3 is pancreas-specific. Full-length human p16INK4a shares 63% aa identity with mouse p16INK4a. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary, as well as transformed, cells. Recombinant Human p16-INK4a-TAT expressed in E. coli is an 18.0kDa protein containing 167 amino-acid residues, including the 155 residues of full-length p16-INK4a and a 12-residue C-terminal TAT peptide (GYGRKKRRQRRR) . |
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