| 货号 | 规格 | 价格 |
|---|---|---|
| FL031 | ||
| 20μg | ¥198.00 | |
| 100μg | ¥918.00 | |
| 250μg | ¥2280.00 | |
| 1mg | ¥5780.00 |
立即购买
| Appearance | Sterile filtered White lyophilized (freeze-dried) powder. |
|---|---|
| Purity | > 96% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.1 EU/μg of rHuIL-1RA protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Human |
| Tag | Tag free. |
| Activity | Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of ≥ 2.5×10^4 IU/mg in the presence of 50 pg/ml rHuIL-1α. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 150 mM NaCl pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | P18510 Arg26-Glu177 |
|---|---|
| Amino acid sequence | RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE |
| Molecular weight | Approximately 17.2 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids. |
| Synonyms | IL-1Ra, ICIL-1RA, IRAP, IL-1RN |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Human IL-1RA is for research use only and not for use in diagnostic or therapeutic procedures. |
| Interleukin-1 receptor antagonist (IL-1RA) is a member of the IL-1 family. IL1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B) , and modulates a variety of interleukin 1 related immune and inflammatory responses. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-RA. The regulated expression of IL1RA in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1RA is markedly enhanced by IL-1, TNF-alpha, or PDGF. The protein shows 26% amino acid homology to IL1β and 19% homology to IL1α. Recombinant Human IL-1RA is a 17.2kDa protein consisting of 153 amino acid residues. |
总篇数：加载中...
总影响因子：加载中...
最高影响因子：加载中...
上海市闵行区新骏环路760号1号楼3层
400-058-8030
技术支持(电话/微信)：
张老师 18217238522
罗老师 15021027255
李老师 18301721288
如有任何关于雅酶产品问题
欢迎来信咨询
雅酶微信公众号
Copyright © 2023上海雅酶生物医药科技有限公司（Epizyme Biotech）
沪ICP备2021002422号
