| 货号 | 规格 | 价格 |
|---|---|---|
| FL003 | ||
| 5μg | ¥328.00 | |
| 25μg | ¥918.00 | |
| 100μg | ¥3180.00 | |
| 250μg | ¥6580.00 | |
| 500μg | ¥9180.00 | |
| 1mg | ¥16800.00 |
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| Appearance | Sterile filtered White lyophilized (freeze-dried) powder. |
|---|---|
| Purity | > 95% by SDS-PAGE or HPLC. |
| Endotoxin | < 0.01 EU/μg of rRtIL-17A protein as determined by LAL method. |
| Expression System | Expressed in E. coli. |
| Species | Rat |
| Tag | Tag free. |
| Activity | Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of ≥ 1.0×10^6 IU/mg. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 300 mM NaCl, pH 6.5. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Accession # | Q61453 Ala18-Ser150 |
|---|---|
| Amino acid sequence | AVLIPQSSVCPNAEANNFLQNVKVNLKVINSLSSKASSRRPSDYLNRSTSPWTLSRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPEKCPFTFRVEKMLVGVGCTCVSSIVRHAS |
| Molecular weight | Approximately 30 kDa, a homodimer of two 133 amino acids polypeptide chains. |
| Synonyms | IL-17, CTLA-8 |
| Stability & Storage | Shipped on wet ice. For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution. |
| Precautions | Recombinant Rat IL-17A is for research use only and not for use in diagnostic or therapeutic procedures. |
| The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 1333 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Human Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The six known members of this family are secreted as homodimers. Mature rat IL-17A shares 60% and 89% amino acid sequence identity with human and mouse IL-17A, respectively. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Rat IL-17A is a 30.0kDa, disulfide-linked homodimer of two 133 amino acid polypeptide chains. |
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