Purified APC-conjugated Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| F105115 | ||
| 25T | ¥718.00 | |
| 100T | ¥1780.00 |
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![APC Mouse Anti-Human IgM [86M56M53]](https://cdn.epizyme.cn/uploads/products/202606/F105115-1.png?v=20260617092708)
| Product Name | APC Mouse Anti-Human IgM |
|---|---|
| Description | Purified APC-conjugated Recombinant Mouse Monoclonal Antibody |
Application
|
FC |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 86M56M53 |
| Isotype | IgG1, κ |
| Label | APC (Ex/Em: 651/660 nm) |
| Immunogen | Recombinant protein of human IgM |
| Format | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA. |
| Recommended Usage | 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. |
|---|---|
| Synonyms | Igh-6; Ighm; Immunoglobulin heavy constant mu. |
| Uniprot ID | P01871 |
| Gene ID | 3507 |
| Storage | Shipped on wet ice. Store undiluted between 2℃ and 8℃ and protected from prolonged exposure to light. Do not freeze. |
| Precautions | APC Mouse Anti-Human IgM [86M56M53] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010] |
|---|
| Cellular Location | Isoform 1: Secreted; Note: During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM. Isoform 2: Cell membrane ; Single-pass membrane protein. |
|---|
| Tissue Location | Secreted protein expression in several tissues. |
|---|
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