Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| MR00001 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
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![Anti-ErbB2/HER2 Mouse mAb [23L213H6]](https://files.epizyme.cn:5005/uploads/productimage/c95d6711faff4598bd343498e28bdd62.jpg)
![Anti-ErbB2/HER2 Mouse mAb [23L213H6]](https://files.epizyme.cn:5005/uploads/productimage/a986efd140124066b9cf21e0ca135321.jpg)
| Product Name | Anti-ErbB2/HER2 Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
ELISA, IF (Cell)/ICC, IHC-P, IF (Tissue-P), FC |
| Dilution | ICC/IF 1:100~1:1,000; IHC-P 1:100; FC 1:100~1:1,000; ELISA 1:1,000 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 23L213H6 |
| Isotype | IgG1 |
| Label | Unconjugated |
| Immunogen | Recombinant anti-ErbB2/HER2 monoclonal antibody recognizes endogenous levels of total ErbB2/HER2 protein. |
| Format | Purified monoclonal antibody supplied in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. This antibody is purified through a protein G column. |
| Synonyms | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, C erb B2/neu protein, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, Erb b2 receptor tyrosine kinase 2, ErbB-2 proto-oncogene, ERBB2, ERBB2_HUMAN, HER 2, HER 2/NEU, HER2, Herstatin, Human epidermal growth factor receptor 2, Metastatic lymph node gene 19 protein, MLN 19, MLN19, NEU, NEU proto oncogene, Neuro/glioblastoma derived oncogene homolog, Neuroblastoma/glioblastoma derived oncogene homolog, NGL, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase type cell surface receptor HER2, Tyrosine kinase-type cell surface receptor HER2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). |
|---|---|
| Calculated MW | 138 kDa |
| Uniprot ID | P04626 , P06494 |
| Gene ID | 2064 |
| Storage | Shipped on wet ice. Store at -20℃. Stable for 24 months from date of receipt. Aliquoting is unnecessary for -20℃ storage. |
| Precautions | Anti-ErbB2/HER2 Mouse mAb is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. |
|---|
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). [Isoform 3]: Cytoplasm. Nucleus. |
|---|
| Tissue Location | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
|---|
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