Purified Recombinant Mouse Monoclonal Antibody
| 货号 | 规格 | 价格 |
|---|---|---|
| M900003 | ||
| 20µL | ¥588.00 | |
| 50µL | ¥1080.00 | |
| 100µL | ¥1780.00 |
| Product Name | Anti-RAB7A Mouse mAb |
|---|---|
| Description | Purified Recombinant Mouse Monoclonal Antibody |
Application
|
WB, IF (Cell), ELISA |
| Dilution | WB 1:1,000~1:5,000; IF 1:100 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 24D164D1 |
| Isotype | IgG |
| Target / Specificity | This RAB7A antibody is generated from mice immunized with a SHC (Shrimp Hemocyanin) conjugated synthetic peptide between 187-201 amino acids from human RAB7A. |
| Format | Purified monoclonal antibody supplied in PBS with 0.01% sodium azide and 50% glycerol, pH 7.3. This antibody is purified through a protein G column. |
| Gene ID | 7879 |
|---|---|
| Synonyms | RAB7A_HUMAN; Ras-related protein Rab-7a; EC:3.6.5.2; RAB7 |
| Calculated MW | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Primary Accession | P51149 |
| Other Accession | NP_004628.4 |
| Antigen Region | 187-201 aa |
| Storage | Shipped at 4℃. Upon delivery aliquot. Store at 4℃ short term (1~2 weeks). Store at -20℃ for 2 years. Avoid freeze / thaw cycles. |
| Precautions | Anti-RAB7A Mouse mAb is for research use only and not for use in diagnostic or therapeutic procedures. |
| Background | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). |
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| Cellular Location | Cytoplasmic vesicle; Endosome; Lipid droplet; Lysosome; Membrane; Mitochondrion. |
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